Low Serum Creatinine as a Predictor of Prolonged Mechanical Ventilation and Weaning Failure

The main objective of the study is to determine whether a subnormal serum creatinine value upon admission to the Post-ICU Care Unit predicts the need for prolonged ventilatory support. A parallel objective of the study is to determine whether exogenous in-take of the dietary supplement creatine in patients with subnormal serum creatinine value is associated with a shortened duration of ventilatory support and improved patients outcome.

NCT Number	NCT07177183
Lead Sponsor	University Hospital Ostrava
Conditions	Prolonged Mechanical Ventilation, Critical Illness
Enrollment	492 participants
Start Date	2026-02-02
Primary Completion	2027-12-31 (estimated)
Study Completion	2028-02-02 (estimated)
Updated on ClinicalTrials.gov	2026-02-05