MULTIVALVE : A Prospective Multicentre Study of Multiple and Mixed Valvular Heart Disease

Multiple and mixed valvular heart disease (MMVD) is a common condition in clinical practice. It corresponds to a combination of stenotic or leaky lesions on two or more heart valves (multiple valve disease), or a combination of stenotic and leaky lesions on the same valve (mixed valve disease). However, the management of their clinical, biological and cardiovascular imaging is not well established. Current European Society of Cardiology (ESC) recommendations primarily address the various valve diseases in isolation. This results in an absence of reliable recommendations for managing MMVD, with different approaches being adopted by care centres. In order to address this knowledge gap regarding MMVD, it is crucial to assess its prevalence, the cardiovascular imaging methods employed and the management strategies, as well as to identify prognostic factors for the various combinations of valve disease. The multicentre MMVD study will be a valuable resource as it will improve our understanding of the prognosis for patients with MMVD. It will highlight imaging and biological markers associated with the prognosis of different combinations of MMVD.

NCT Number	NCT07176507
Lead Sponsor	French Cardiology Society
Conditions	Valvular Heart Disease
Enrollment	1,000 participants
Start Date	2025-10-30
Primary Completion	2028-10 (estimated)
Study Completion	2032-10 (estimated)
Updated on ClinicalTrials.gov	2026-06-12