Clinical Trial

Clinical Efficacy of Intermittent Theta Burst Transcranial Magnetic Stimulation With Different Modes on Parkinson's Disease

Enrolling by Invitation
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Summary
TMS regulates cortical excitability through electromagnetic induction, with low-frequency stimulation suppressing and high-frequency stimulation enhancing excitability. Building on theta-gamma coupling, iTBS induces broader improvements in functional brain connectivity within a shorter stimulation period, particularly by significantly reducing abnormal variability in the prefrontal and parietal regions, demonstrating superior neuromodulatory efficiency and network remodeling capacity. This study aims to compare the symptomatic effects of different iTBS protocols on Parkinson's disease, optimize stimulation parameters, and evaluate safety, while also analyzing the time-dependent trends of therapeutic efficacy through 1- and 3-month follow-ups.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-09-09.
Trial Details
NCT Number NCT07176091
Lead Sponsor Second Affiliated Hospital of Soochow University
Conditions Parkinsonism, Transcranial Magnetic Stimilation, Intermittent Theta Burst Stimulation, Primary Motor Cortex, Electroencephalography, Neuromodulation
Enrollment 90 participants
Start Date 2025-01-01
Primary Completion 2027-03-01 (estimated)
Study Completion 2027-06-01 (estimated)
Updated on ClinicalTrials.gov 2026-02-13