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Clinical Efficacy of Intermittent Theta Burst Transcranial Magnetic Stimulation With Different Modes on Parkinson's Disease

StatusEnrolling by Invitation
PhaseNot applicable
Started
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Record History

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  1. Enrollment target: 40 to 90v2 Show 6 more changesShow less
    • Interventions: Combined treatment of tDCS and rTMS (Device), sham-tDCS combined with real TMS (Device) to High-dose iTBS treatment group (Procedure), Low-dose iTBS treatment group (Procedure), Sham stimulation group (Procedure)
    • Eligibility criteria shortened, about 158 words
    • Secondary endpoints: 9 to 11
    • Study description expanded, about 55 words
    • Study arms: 2 to 3
    • Study title shortened, about 2 words
  2. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
TMS regulates cortical excitability through electromagnetic induction, with low-frequency stimulation suppressing and high-frequency stimulation enhancing excitability. Building on theta-gamma coupling, iTBS induces broader improvements in functional brain connectivity within a shorter stimulation period, particularly by significantly reducing abnormal variability in the prefrontal and parietal regions, demonstrating superior neuromodulatory efficiency and network remodeling capacity. This study aims to compare the symptomatic effects of different iTBS protocols on Parkinson's disease, optimize stimulation parameters, and evaluate safety, while also analyzing the time-dependent trends of therapeutic efficacy through 1- and 3-month follow-ups.
Trial Details
NCT Number NCT07176091
Lead Sponsor Second Affiliated Hospital of Soochow University
Conditions
(from sponsor)		 Parkinsonism, Transcranial Magnetic Stimilation, Intermittent Theta Burst Stimulation, Primary Motor Cortex, Electroencephalography, Neuromodulation
Related terms Parkinsonian Disorders
Enrollment 90 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov