Clinical Trial

Methylprednisolone vs Dexamethasone Interaction With Sugammadex in Pediatric Patients

Completed
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Summary
This randomized controlled trial aims to compare the interaction of methylprednisolone and dexamethasone with sugammadex in pediatric patients undergoing adenoidectomy and/or tonsillectomy. The primary objective is to evaluate the effect of these corticosteroids on the reversal time of rocuronium-induced neuromuscular block by sugammadex. Secondary outcomes include postoperative pain, nausea and vomiting, extubation time, and adverse events. Eligible participants are children aged 5 to 12 years, ASA I-II, scheduled for elective surgery under general anesthesia. The study is designed as a triple-blind, parallel-group trial with three arms: methylprednisolone, dexamethasone, and placebo.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2025-09-09; most recent amendment 2025-12-26.
Status change: Recruiting → Completed 2025-12-26
Status change: Not Yet Recruiting → Recruiting 2025-09-18
Trial Details
NCT Number NCT07175623
Lead Sponsor Konya City Hospital
Conditions Neuromuscular Block, Residual, Pain Management, Postoperative Nausea
Enrollment 60 participants
Start Date 2025-09-16
Primary Completion 2025-12-20 (estimated)
Study Completion 2025-12-20 (estimated)
Updated on ClinicalTrials.gov 2025-12-29