Early Double Sequential Defibrillation in Out of Hospital Cardiac Arrest

Some of the patients affected by Out-of-hospital cardiac arrest (OHCA) with ventricular fibrillation (VF)/ventricular tachycardia (VT) do not respond to initial defibrillation. The survival decreases with number of defibrillations required to terminate VF/VT. In 2022, one prospective cluster randomized trial showed increased survival among (OHCA) patients in refractory VF using Double Sequential Defibrillation (DSD). If DSD can increase survival among all patients in VF that dont respond to one defibrillation, i.e. before it has become refractory is not known. The aim of this trial is to assess survival with a double defibrillation strategy initiated as soon as possible among patients with Out of Hospital Cardiac Arrest with initial shockable rhythm and at least one failed standard defibrillation, compared with continued resuscitation using standard defibrillation.

NCT Number	NCT07174986
Lead Sponsor	Gabriel Riva Collaborators: Swedish Heart Lung Foundation, Region Stockholm, Vastra Gotaland Region, Region Halland, Laerdal Foundation
Conditions	Out of Hospital Cardiac Arrest, Ventricular Fibrillation, Defibrillation, CPR, ACLS, Sudden Death
Enrollment	916 participants
Start Date	2025-09-08
Primary Completion	2028-12-31 (estimated)
Study Completion	2029-12 (estimated)
Updated on ClinicalTrials.gov	2026-02-17