Testing of a New Rapid Antigen Test for Plague in Ituri, Democratic Republic of the Congo.

This study is being done to learn more about the disease in Ituri and to evaluate a new rapid test that may help doctors find the disease more quickly. This research includes characterisation of clinical presentations and pathology of plague, as well as identification of circumstances that may increase the risk of infection. Biological samples collected include blood, mouth swab, saliva, a bubo aspirate and a sputum sample (the latter only in case of plague in the lungs). These samples will be used to test the performance of the new rapid study test.

NCT Number	NCT07174648
Lead Sponsor	Institute of Tropical Medicine, Belgium Collaborators: Institut Pasteur, Université Paris-Saclay, Centre de Recherche en Maladies Tropicales de L'Ituri (CRMT), Institut National pour la Recherche Biomedicale (INRB)
Conditions	Plague, Bubonic; Plague, Skin, Plague, Pneumonic
Enrollment	300 participants
Start Date	2026-05-01
Primary Completion	2029-01-02 (estimated)
Study Completion	2029-01-02 (estimated)
Updated on ClinicalTrials.gov	2026-03-27