Brief Summary The goal of this observational study is to establish a comprehensive biobank and phenotypic data repository for patients diagnosed with bipolar disorder in Türkiye. The study will prospectively collect standardized clinical, demographic, lifestyle, and biological data to create a secure genomic and epigenomic research resource.
The main questions it aims to answer are:
Can large-scale, standardized phenotypic and biological data collection improve the understanding of bipolar disorder subtypes and disease course?
Can integration of biobank samples with genomic and epigenomic analyses identify biomarkers that inform future diagnosis, prognosis, and treatment strategies?
Participants will:
Provide consent and demographic/clinical information using the NeuroPsyBiT Data Collector software.
Contribute blood samples (e.g., EDTA tubes) for DNA extraction, genotyping, and future epigenomic studies.
Allow secure storage of their data and biospecimens in the RTSGD biobank for use in ethically approved research projects.
All data and samples will be collected and stored under strict ethical oversight and in compliance with national (KVKK) and international (GDPR) data protection regulations. Personally identifiable information will not be shared, and access to the biobank and dataset will only be granted after approval by institutional review boards and ethics committees.
This registry will create the foundation for future genome-wide association studies (GWAS) and epigenome-wide association studies (EWAS), supporting the long-term goal of developing precision psychiatry tools for bipolar disorder.