Clinical Trial

The Effect of Continuous Versus Intermittent Enteral Nutrition on Metabolic Outcomes in Critically Ill Patients

Study acronym: CONVEnIENT
Recruiting
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Summary
The goal of this clinical trial is to investigate the effect of continuous versus intermittent enteral nutrition on metabolic outcomes in critically ill adult patients. The aim of this study is to: • To assess the effect of a daytime intermittent tube feeding pattern compared to standard continuous tube feeding on glycaemic control, gastrointestinal function, gastrointestinal hormones, markers of sleep quality and circadian rhythm, and lean body mass and body composition. Participants will receive either continuous enteral nutrition for 24 hours a day or intermittent enteral nutrition during the day, consisting of 4 portions each administered over 1 hour between 8 am and 8 pm. The maximum duration of the intervention is 5 days or until participants do not receive exclusive gastric enteral nutrition.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2025-09-11; most recent amendment 2026-03-11.
Status change: Not Yet Recruiting → Recruiting 2025-09-30
Trial Details
NCT Number NCT07173504
Lead Sponsor Gelderse Vallei Hospital
Collaborators: ZonMw: The Netherlands Organisation for Health Research and Development, Wageningen University and Research
Conditions Critical Illness
Enrollment 124 participants
Start Date 2025-09-30
Primary Completion 2028-06 (estimated)
Study Completion 2028-09 (estimated)
Updated on ClinicalTrials.gov 2026-03-13