Clinical Trial

A RCT to Determine the Effect of ENDS Flavor Availability on Abstinence Within Smokers

Terminated
View on ClinicalTrials.gov →
Why the trial stopped
The study was terminated due to data integrity concerns that affected the ability to reliably assess the study endpoints.
Summary
The overall purpose of this study will be to assess primary combustible cigarette users' abstinence from smoking their usual brand of combustible cigarettes at the end of the study, when provided with an electronic nicotine delivery system (ENDS) power unit (2) and varying levels of access to tobacco-flavored, menthol-flavored, or non-tobacco/non-menthol-flavored cartridge-based e-liquids (collectively referred to as the investigational product) within their assigned study arm over a three-month (ninety-day) period.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2025-09-11; most recent amendment 2026-02-25.
Status change: Recruiting → Terminated 2026-02-25
Status change: Not Yet Recruiting → Recruiting 2025-10-01
Trial Details
NCT Number NCT07172438
Lead Sponsor RAI Services Company
Conditions Smoking, Tobacco
Enrollment 668 participants
Start Date 2025-09-17
Primary Completion 2026-01-14 (estimated)
Study Completion 2026-01-14 (estimated)
Updated on ClinicalTrials.gov 2026-02-27