Single vs Multi-Dose Insulin for Glycemic Control (SUGAR)

The goal of this clinical trial is to see if diabetes in pregnancy can be treated with once daily dosing of insulin instead of once daily dosing plus insulin with meals. The main question this study aims to answer is: 1. Can a once daily dose of long-acting insulin control blood sugars as well as long-acting insulin plus meal-time insulin? 2. Do babies born to mothers who take one dose of long-acting insulin have more complications after birth than babies born to mothers who take long-acting and meal-time insulin? Researchers will compare one dose of long-acting insulin per day to this plus three doses of short-acting insulin with each meal to see if blood sugars are controlled. Participants will send their blood sugar logs to the study staff weekly, instead of to their OB/GYN, for adjustments to their insulin dosing.

NCT Number	NCT07171684
Lead Sponsor	Rutgers, The State University of New Jersey Collaborators: NYU Langone Health
Conditions	Diabetes in Pregnancy, Gestational Diabetes
Enrollment	176 participants
Start Date	2025-11-26
Primary Completion	2026-10-01 (estimated)
Study Completion	2027-05-15 (estimated)
Updated on ClinicalTrials.gov	2026-04-16