Components of Mechanical Power on the Functional Lung in ARDS

Mechanical power (MP) is a composite variable that integrates static and dynamic respiratory parameters and has been associated with ventilator-induced lung injury (VILI). MP is predominantly delivered to the reduced functional lung size, commonly referred to as the "baby lung" (BL). Functional lung size, in turn, is closely related to respiratory system compliance (Crs). Previous studies have demonstrated an association between MP normalized to compliance (MP/Crs) and mortality. Moreover, evidence suggests that VILI associated with MP/Crs results primarily from the combined effect of its components rather than from any single component in isolation. The objective of this study is to evaluate both the overall and the relative contribution of each component of mechanical power, normalized to compliance (MP/Crs), to in-hospital mortality in patients with acute respiratory distress syndrome (ARDS).

NCT Number	NCT07171632
Lead Sponsor	Ramos Mejía Hospital Collaborators: Universidad de la Republica
Conditions	Respiratory Distress Syndrome (RDS)
Enrollment	184 participants
Start Date	2025-12-01
Primary Completion	2026-12-01 (estimated)
Study Completion	2027-03-10 (estimated)
Updated on ClinicalTrials.gov	2025-12-04