Efficacy of a Wearable Noninvasive Neuromodulation Device

The aim of this study is to investigate the potential of transcutaneous neuromodulation (TNM) to treat slow colonic transit and constipation, termed the Neurogenic bowel dysfunction (NBD), in people with SCI. In this project, the study team will investigate the impact of an active treatment intervention vs. a sham control intervention on NBD symptoms in patients with SCI. The study hypotheses: * The proposed TNM treatment at a leg point will reduce NBD symptoms between baseline and post-therapy, when compared to the sham-TNM treatment. * The therapeutic effect of TNM to improve the NBD symptoms is associated with improvement of the autonomic function in SCI patients.

NCT Number	NCT07171489
Lead Sponsor	University of Michigan Collaborators: National Institute of Neurological Disorders and Stroke (NINDS)
Conditions	Spinal Cord Injuries
Enrollment	100 participants
Start Date	2026-07
Primary Completion	2029-11 (estimated)
Study Completion	2029-11 (estimated)
Updated on ClinicalTrials.gov	2026-07-06