Predictors of GON Blockade Success in Migraine

This multicenter, prospective cohort study aims to identify clinical and demographic predictors that influence the success of greater occipital nerve (GON) block in patients with migraine. Patients will be evaluated at baseline, on each injection day, and at one- and three-month follow-ups. Study parameters include demographics, migraine type and duration, comorbidities, headache characteristics, treatment history, and validated outcome measures such as the Numeric Rating Scale (NRS), Headache Impact Test-6 (HIT-6), and Global Rating of Change (GRoC). The goal is to establish predictive factors of treatment success in order to optimize patient selection and contribute robust multicenter evidence to individualized migraine management

NCT Number	NCT07170111
Lead Sponsor	Başakşehir Çam & Sakura City Hospital Collaborators: Umraniye Education and Research Hospital, Gaziantep City Hospital, Namik Kemal University School of Medicine, Tekirdag, Bakırçay University, Faculty of Medicine
Conditions	Migraine
Enrollment	460 participants
Start Date	2025-09-15
Primary Completion	2026-11-01 (estimated)
Study Completion	2026-12-01 (estimated)
Updated on ClinicalTrials.gov	2025-09-12