Post-operative Pain After Different Irrigation and Disinfection Methods in Single-rooted Teeth

This randomized clinical trial aimed to evaluate post-operative pain (PP) in single-rooted teeth with asymptomatic apical periodontitis following final irrigation with sonic activation systems (EDDY and EndoActivator), with and without adjunctive 980-nm diode laser disinfection. Eighty patients were randomized into four groups: Group 1 (EDDY), Group 2 (EndoActivator), Group 3 (EDDY + laser), and Group 4 (EndoActivator + laser). PP intensity and analgesic intake were recorded at 8, 24, 48 hours, and on day 7. The study found no significant differences in PP or analgesic use among the groups, indicating that laser-assisted or different sonic activation methods did not reduce post-operative pain.

NCT Number	NCT07170098
Lead Sponsor	Biruni University
Conditions	Post Operative Pain, Apical Periodontitis, Asymptomatic Infections
Enrollment	80 participants
Start Date	2025-08-10
Primary Completion	2025-08-11 (estimated)
Study Completion	2025-10-31 (estimated)
Updated on ClinicalTrials.gov	2026-01-12