Study of PSMA PET/CT Imaging to Help Select Men With Low-Risk Prostate Cancer for Active Surveillance

This is a multicenter, prospective diagnostic accuracy study evaluating the Istanbul PSMA PET/CT Criteria (IPPC) for selecting patients with biopsy-confirmed low-risk prostate cancer (ISUP Grade 1) for active surveillance (AS). The study integrates delayed Ga-68 PSMA PET/CT imaging into the diagnostic pathway to refine patient stratification, minimize overtreatment and potentially reduce unnecessary biopsies and MRI, or exposing high-risk individuals to the danger of cancer progression if left untreated scans.

NCT Number	NCT07168616
Lead Sponsor	Istanbul University - Cerrahpasa Collaborators: Yeditepe University, Yedikule Training and Research Hospital, Acibadem University, Ankara Yildirim Beyazıt University, University of Gaziantep, Istanbul Training and Research Hospital, Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital, Sisli Hamidiye Etfal Training and Research Hospital, Haseki Training and Research Hospital
Conditions	Low Risk Prostate Cancer, Clinically Significant Prostate Cancer
Enrollment	201 participants
Start Date	2025-09-01
Primary Completion	2026-09-15 (estimated)
Study Completion	2028-06-01 (estimated)
Updated on ClinicalTrials.gov	2025-09-15