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Optimizing Preeclampsia Postpartum With Point-of-care Ultrasound

Study acronym: PPPOCUS
StatusNot Yet Recruiting
PhasePhase 4
Started
View on ClinicalTrials.gov ↗

Record History

  1. Notable Primary completion date: Nov 8, 2025 to Jun 15, 2028 Start date: Nov 1, 2025 to Jun 15, 2026 · Trial status: Enrolling by Invitation to Not Yet Recruiting · Completion date: Mar 15, 2027 to Jun 15, 2028v3 Show 3 more changesShow less
    • Start date: Nov 1, 2025 to Jun 15, 2026
    • Trial status: Enrolling by Invitation to Not Yet Recruiting
    • Completion date: Mar 15, 2027 to Jun 15, 2028
  2. Notable Primary completion date: Mar 2, 2027 to Nov 8, 2025 Start date: Sep 2, 2025 to Nov 1, 2025v2 Show 1 more changeShow less
    • Start date: Sep 2, 2025 to Nov 1, 2025
  3. Minor Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This study explores a novel approach to improving care for postpartum patients with preeclampsia, a pregnancy-related condition characterized by high blood pressure, protein in the urine, and organ dysfunction. Preeclampsia affects up to 9% of pregnancies and can progress to include complications of seizures, stroke, and even death. Over 60% of patients with preeclampsia continue to experience high blood pressure at the time of discharge from their delivery hospitalization, and many of these patients require blood pressure medications for up to 6 months postpartum. Even with blood pressure medications, many of these patients are readmitted to the hospital within six weeks of delivery. In this study, the investigators will utilize point-of-care ultrasound (POCUS), a quick and non-invasive, bedside imaging strategy, to look for signs of excess fluid accumulating in the lungs and venous system of postpartum patients with preeclampsia. Because excess fluid has the potential to worsen blood pressure, subjects with evidence of this on POCUS would be treated with a diuretic medication called furosemide (either orally or intravenously) within 24 hours of delivery. The investigators' main goal is to determine whether using POCUS can help physicians make better treatment decisions and improve short-term outcomes for postpartum patients with preeclampsia. The investigators' aim to achieve faster recovery of blood pressure, reduce the need for blood pressure medication at hospital discharge, and lower the rates of hospital readmission for those with preeclampsia. This study could significantly enhance the overall care and health of postpartum patients.
Trial Details
NCT Number NCT07167862
Lead Sponsor University of California, Irvine
Conditions Preeclampsia, Preeclampsia Postpartum, Preeclampsia Severe or Mild
Enrollment 96 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov