The Effect of Mobilization on Inflammatory Biomarkers in Patients With Knee Osteoarthritis.

This study is designed to investigate whether a hands-on therapy called Mobilization with Movement (MWM) can reduce pain and inflammation in individuals with knee osteoarthritis (OA). The investigators will compare MWM to a sham treatment that resembles mobilization but does not involve the specific therapeutic movements. Both groups will also receive standard care, including exercise and education about managing knee OA. A total of 40 adults (aged 18 years and older) with moderate to severe knee OA will be enrolled. Participants will be randomly assigned to either the MWM group or the sham group. Each intervention will be delivered twice per week over a four-week period. Outcomes will include measures of inflammation obtained from blood samples, self-reported pain levels, and assessments of knee function before and after the intervention period. It is hypothesized that individuals allocated to the MWM group will demonstrate reduced inflammation and pain compared with those in the sham group. The findings of this study may help clarify the potential role of MWM as a treatment option for knee OA.

NCT Number	NCT07166068
Lead Sponsor	University of Jazan
Conditions	Knee Osteoarthritis
Enrollment	40 participants
Start Date	2025-09-20
Primary Completion	2026-02-20 (estimated)
Study Completion	2026-04-20 (estimated)
Updated on ClinicalTrials.gov	2025-12-09