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Comparative Study of Tranexamic Acid Dosing in Cardiac Surgery

StatusRecruiting
PhaseNot applicable
Started
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Record History

  1. Study First Submitted
Tranexamic axid is routinely used as an antifibrinolytic agent in cardiac surgery to reduce the risk of blood loss and transfusion. However, there is no consensus regarding the dosage regimen of tranexamic acid that should be administered. The purpose of this study is to compare different dosages of tranexamic acid in cardiac surgery using cardiopulmonary bypass regarding the duration of inhibition of fibrinolysis as measured by the ClotPro test. Blood samples will be taken from the arterial line placed in the patient at specified time points in order to perform viscoelastic tests (ClotPro, TPA test), to detect successful inhibition of fibrinolysis and to measure tranexamic acid levels in the patient's blood. In case the action of tranexamic acid stops early postoperatively an additional dose of the medication will be administered to the patient.
Trial Details
NCT Number NCT07164300
Lead Sponsor University of Ioannina
Conditions
(from sponsor)		 Blood Coagulation Disorder, Postoperative Blood Loss, Adverse Drug Event, Fibrinolysis; Hemorrhage, Tranexamic Acid Adverse Reaction
Related terms Blood Coagulation Disorders, Drug-Related Side Effects and Adverse Reactions, Hemorrhage, Postoperative Hemorrhage
Enrollment 150 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov