SAVE: School Ambassadors for Vaccine Education

Influenza is associated with millions of cases of school absenteeism due to illness, hundreds of hospitalizations and thousands of deaths in the U.S. each year, which can be greatly reduced with influenza vaccination. The goal of this randomized controlled trial is to learn if training school personnel in vaccine communication techniques and equipping schools with vaccine promotional materials targeting students and their parents/guardians increases the influenza vaccination rates of the student population within participating schools. The main question it aims to answer is: -Will flu vaccination rates be higher in intervention schools compared to control schools by the end of the intervention period? Participating schools will: * Have select school personnel (school nurses, coaches, teachers, etc.) complete an online training module and optional training workshop focused on vaccine communication \[intervention arm only\] * Utilize vaccine promotional materials (posters, flyers, digital files for social media, etc.) provided by the study team during flu season \[intervention arm only\] * Track student vaccination rates \[intervention + control arm\]

NCT Number	NCT07164144
Lead Sponsor	University of Rochester Collaborators: Centers for Disease Control and Prevention
Conditions	Influenza Vaccination
Enrollment	6,000 participants
Start Date	2026-04-01
Primary Completion	2027-08-01 (estimated)
Study Completion	2027-09-01 (estimated)
Updated on ClinicalTrials.gov	2026-03-05