Clinical Trial

Efficacy of Flurbiprofen Spray for Postoperative Sore Throat Following Double-Lumen Endobronchial Intubation

Study acronym: FLURBI-POST
Active, Not Recruiting
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Summary
The goal of this study is to evaluate whether topical flurbiprofen reduces the incidence and severity of postoperative sore throat (POST) and hoarseness in patients undergoing double-lumen tube (DLT) intubation for elective thoracic surgery. The main question is: Does topical flurbiprofen reduce POST and hoarseness compared with placebo in patients undergoing DLT intubation? Researchers will compare topical flurbiprofen spray with placebo spray. Participants will: * Receive a DLT sprayed with either topical flurbiprofen or placebo before intubation. * Be assessed for POST and hoarseness at 15 minutes, 2 hours, 12 hours, 24 hours, and 48 hours after surgery.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2025-09-01; most recent amendment 2026-03-22.
Status change: Not Yet Recruiting → Active, Not Recruiting 2026-03-22
Trial Details
NCT Number NCT07163429
Lead Sponsor Kittitorn Supphapipat, MD
Conditions Post Operative Sore Throat, Hoarseness
Enrollment 58 participants
Start Date 2025-09-10
Primary Completion 2026-12-31 (estimated)
Study Completion 2027-06-30 (estimated)
Updated on ClinicalTrials.gov 2026-03-24