Characterizing Transcranial Focused Ultrasound Neuromodulation During Sedation

The goal of this clinical trial is to learn if focused ultrasound delivered to the brain influences the effects of the anesthetic medication propofol. It will also learn about the safety and feasibility of using ultrasound and anesthesia together to influence the brain. The main questions it aims to answer are: * Does focused ultrasound delivered to the brain influence the effects or the strength of propofol? * Does propofol anesthesia influence the effects of ultrasound delivered to the brain? Researchers will compare focused ultrasound with sham ultrasound (similar technology but not targeted to a brain region) and administer propofol anesthesia, while measuring signals from the brain and behaviors of participants. Participants will: * Obtain one non-contrast MRI scan of the brain * Receive two separate sessions of ultrasound to the brain (one focused and one sham) * Undergo two separate sessions of propofol anesthesia in a laboratory

NCT Number	NCT07161518
Lead Sponsor	Stanford University
Conditions	Healthy Participants
Enrollment	10 participants
Start Date	2025-09-01
Primary Completion	2027-08 (estimated)
Study Completion	2027-08 (estimated)
Updated on ClinicalTrials.gov	2026-03-10