Personalized Theta-burst Stimulation for Long-lasting Changes in Approach/Avoidance Behavior

This study will assess the long-lasting effects of personalized theta burst stimulation (TBS), a repetitive form of transcranial magnetic stimulation (TMS), over the left prefrontal cortex on the approach/avoidance behavior. TBS will be personalized based on the prefrontal theta rhythm captured with electroencephalography (EEG). The main questions it aims to answer are: 1. does a single session of personalized TBS synchronized with the individual theta rhythm over the left prefrontal cortex results in the outlasting changes in the individual behavior? 2. Does TBS results in the brain rhythms' changes as measured using resting-state EEG?

NCT Number	NCT07161505
Lead Sponsor	Northwestern University Collaborators: National Institute of Mental Health (NIMH)
Conditions	Approach/Avoidance Behavior
Enrollment	26 participants
Start Date	2025-07-31
Primary Completion	2026-08-31 (estimated)
Study Completion	2026-08-31 (estimated)
Updated on ClinicalTrials.gov	2025-09-08