Clinical Trial

Effect of Foot Reflexology on Anxiety

Study acronym: REFLEX-ANS
Enrolling by Invitation
View on ClinicalTrials.gov →
Record status
This record was last updated November 28, 2025 (before its estimated November 30, 2025 completion). Its status may not reflect the trial's current state.
Summary
This randomized, sham-controlled, parallel, double-blind clinical trial investigates the effects of foot reflexology on anxiety and well-being in adults with anxiety disorders. Participants are randomized (1:1) to receive either standardized foot reflexology or sham massage for 10 sessions (twice per week, 5 weeks). The primary outcome is the change in Beck Anxiety Inventory (BAI) score from baseline to the 10th session. Secondary outcomes include BAI score at 30-day follow-up, relaxation and well-being assessed immediately after each session with the Profile of Mood States (POMS - Brazilian version, Tension-Anxiety subscale), and incidence of adverse events. It is hypothesized that foot reflexology will result in a greater reduction of anxiety symptoms compared to sham massage.
Protocol Amendment History 3 amendments
This ClinicalTrials.gov record has been amended 3 times since 2025-08-30; most recent amendment 2025-11-24.
Trial Details
NCT Number NCT07161102
Lead Sponsor Carlos Germano Dias Santos
Conditions Anxiety Disorders
Enrollment 44 participants
Start Date 2025-07-30
Primary Completion 2025-11-30 (estimated)
Study Completion 2025-12-05 (estimated)
Updated on ClinicalTrials.gov 2025-11-28