Obstructive Sleep Apnoea and Difficult Asthma (OSADA)

The OSADA (Obstructive Sleep Apnoea in Difficult Asthma) trial is an open-label, randomized control trial investigating the impact of diagnosing and treating obstructive sleep apnoea (OSA) on a asthma control in patients with difficult-to-control asthma. Participants will undergo home-based sleep studies to assess for OSA and are then allocated to one of three arms: 1) Patients with OSA treated with CPAP (intervention group), 2) Patients with OSA not treated for OSA (control group) and 3) Patients without OSA (reference group). The primary objective is to evaluate whether treating OSA improves asthma control, symptom burden, and quality of life compared to untreated OSA and to patients without OSA. Secondary outcomes include exacerbation rates, sleep quality, and healthcare utilization. This trial aims to clarify the contribution of OSA to poor asthma control and the potential benefits of integrated sleep and respiratory care in this complex population.

NCT Number	NCT07160868
Lead Sponsor	St. James's Hospital, Ireland Collaborators: Tallaght University Hospital
Conditions	Asthma (Diagnosis), OSA - Obstructive Sleep Apnea, CPAP Treatment
Enrollment	80 participants
Start Date	2025-09-01
Primary Completion	2026-05-22 (estimated)
Study Completion	2026-05-22 (estimated)
Updated on ClinicalTrials.gov	2026-05-26