Study of Protection And Repair of Endothelial-glycocalyx in Sepsis (SPARES)

Sepsis damages the blood vessel lining and its protective "glycocalyx," contributing to organ failure and death. This pilot, randomized, blinded study will test whether giving fresh frozen plasma (FFP)-either as intermittent boluses or as a continuous infusion-protects or repairs the glycocalyx compared with look-alike placebo fluid (lactated Ringer's with multivitamins), and whether this leads to better clinical outcomes. We will measure blood and urine biomarkers of glycocalyx injury and track organ support needs, ICU/hospital-free days, and survival through 28-90 days.

NCT Number	NCT07160426
Lead Sponsor	Beth Israel Deaconess Medical Center Collaborators: University of Colorado Health
Conditions	Sepsis
Enrollment	45 participants
Start Date	2026-07-01
Primary Completion	2028-06-01 (estimated)
Study Completion	2028-12-01 (estimated)
Updated on ClinicalTrials.gov	2026-04-22