tDCS for Cancer-Related Fatigue and Weakness

This pilot study investigates the effectiveness of non-invasive brain stimulation (tDCS) in alleviating cancer-related fatigue (CRF) and muscle weakness. Using a randomized, double-blind crossover design, participants perform fatiguing muscle tasks with and without tDCS, and outcomes include task endurance, maximal voluntary contraction force, and neuromuscular markers. Neural mechanisms will be assessed via EEG, TMS, and MRI.

NCT Number	NCT07159100
Lead Sponsor	Kessler Foundation
Conditions	Cancer-related Fatigue, Neuromodulation
Enrollment	75 participants
Start Date	2025-09-10
Primary Completion	2027-08-31 (estimated)
Study Completion	2027-12-31 (estimated)
Updated on ClinicalTrials.gov	2025-09-08