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Investigating the Safety and Regenerative Potential of MSC-Derived Secretome Combined With PRGF in Knee Osteoarthritis

Study acronym: PRGFSECKOA
StatusNot Yet Recruiting
PhaseEarly Phase 1
Started
View on ClinicalTrials.gov ↗

Record History

  1. Study First Submitted
This Phase I/II randomized clinical trial investigates the safety, feasibility, and early regenerative potential of intra-articular administration of mesenchymal stem cell (MSC)-derived secretome combined with Plasma Rich in Growth Factors (PRGF) in patients with knee osteoarthritis (KOA). The study aims to assess whether this cell-free, biologically enriched therapeutic combination can reduce pain, improve joint function, and promote cartilage repair.
Trial Details
NCT Number NCT07157891
Lead Sponsor University of the Punjab
Collaborators: Centre of Excellence in Molecular Biology (CEMB), University of the Punjab, Lahore.
Conditions
(from sponsor)		 Osteoarthritis (OA), Knee Injury, Cartilage Degeneration
Related terms Knee Injuries, Osteoarthritis, Osteoarthritis, Knee
Enrollment 25 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov