Impact of Sacubitril/Valsartan on LV Diastolic Function in HFrEF

This prospective cohort study evaluates the effects of six months of sacubitril/valsartan (ARNI) therapy on left ventricular diastolic function in patients with heart failure with reduced ejection fraction (HFrEF) using transthoracic echocardiography. It aims to correlate echocardiographic parameters with clinical status and systolic function among Egyptian patients treated at two cardiology centers.

NCT Number	NCT07157527
Lead Sponsor	Assiut University
Conditions	Left Ventricular Diastolic Function
Enrollment	70 participants
Start Date	2026-06-01
Primary Completion	2027-09-30 (estimated)
Study Completion	2027-12-30 (estimated)
Updated on ClinicalTrials.gov	2025-09-05