Clinical Trial

Oral vs IV Sedation for Cataract Surgery in Older Adults

Study acronym: CatNAPS-2
Completed Phase 4
View on ClinicalTrials.gov →
Summary
The goal of this clinical trial is to evaluate the feasibility of comparing oral sedation (a pill) with intravenous (IV) sedation for cataract surgery in older adults. Investigators will assess the feasibility, completeness, and distribution of data related to postoperative recovery, including thinking and memory, as well as participant satisfaction with care. Participants will be randomly assigned to receive either oral sedation with an IV placebo or IV sedation with an oral placebo before cataract surgery. Participants will complete brief surveys assessing recovery before and after surgery and will be contacted by phone after surgery to assess postoperative recovery. Results from this pilot study will inform the design of a future, fully powered trial evaluating sedation approaches for cataract surgery.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-08-26.
Status change: Recruiting → Completed 2026-04-22
Trial Details
NCT Number NCT07154147
Lead Sponsor University of California, San Francisco
Conditions Cataract Surgery, Sedation, Cognition Function, Perioperative Care, Older Adults
Enrollment 20 participants
Start Date 2025-08-12
Primary Completion 2026-01-19 (estimated)
Study Completion 2026-01-19 (estimated)
Updated on ClinicalTrials.gov 2026-04-27