RT for Adenocarcinoma/Adenosquamous Carcinoma

This study aims to establish a prospective cohort of locally advanced cervical adenocarcinoma to provide a better way to monitor its efficacy and provide precise treatment. The key problems to be solved are as follows: 1. Establish an observational prospective cohort of locally advanced ADC and randomly divide patients with residual cervical tumors in the primary site after CCRT into the local treatment group (salvage surgery or supplementary radiotherapy) or the systemic treatment group. 2. Collect cervical biopsy tissues before and after CCRT in patients with residual cervical tumors, explore the genomic characteristics, and predict whether they can benefit from targeted/immunotherapy in the future.

NCT Number	NCT07153952
Lead Sponsor	Peking Union Medical College Hospital Collaborators: The First Affiliated Hospital of Xiamen University, Heilongjiang Provicial Hospital, Liaoning Cancer Hospital & Institute, Women's Hospital School Of Medicine Zhejiang University, Luohe Central Hospital
Conditions	Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma, Radiotherapy
Enrollment	60 participants
Start Date	2025-01-01
Primary Completion	2027-01-01 (estimated)
Study Completion	2028-01-01 (estimated)
Updated on ClinicalTrials.gov	2025-09-04