Optimal Ablation Strategies for Persistent AF With HF

Atrial fibrillation (AF) in the context of heart failure (HF) is associated with a markedly poor prognosis. Catheter ablation has been shown to improve outcomes in this population, enhancing ablation success rates in these patients is critical for further reducing morbidity and mortality. We conducted this multicenter, randomized clinical trial to systematically evaluate the optimal ablation strategy in patients with heart failure and persistent AF.

NCT Number	NCT07153718
Lead Sponsor	Xu Liu
Conditions	Heart Failure, Persistent Atrial Fibrillation
Enrollment	300 participants
Start Date	2021-01-01
Primary Completion	2026-12-31 (estimated)
Study Completion	2026-12-31 (estimated)
Updated on ClinicalTrials.gov	2025-09-04