Clinical Trial

Efficacy of Perioperative Opioid Sparing Techniques on Time to Initiation of Chemotherapy

Recruiting
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Summary
The primary purpose of this study is to determine if intrathecal morphine (ITM) administration is superior to quadratus lumborum block or surgeon administered transversus abdominis plane (TAP) blocks result in decreased time to initiation of chemotherapy following oncologic surgery. The secondary objectives of this study are to determine: * The difference between interventions in time to return of bowel function in days * The difference between interventions in incidence of opioid related adverse drug events (ORADEs) * The difference between interventions in cumulative and post-operative total morphine milligram equivalents * The difference between interventions in quality-of-life assessment tool and patient satisfaction (brief pain index short form BPI-sf9) * The difference between interventions in hospital length of stay in days * The difference between cumulative pain scores between interventions * The difference between short acting and long-acting bupivacaine in pain management and time to chemotherapy The hypothesis is that preoperative intrathecal morphine administration will significantly reduce the time to initiation of postoperative chemotherapy.
Trial Details
NCT Number NCT07153614
Lead Sponsor University of Tennessee Graduate School of Medicine
Conditions Perioperative Opioid Sparing Techniques
Enrollment 200 participants
Start Date 2025-02-03
Primary Completion 2027-02-03 (estimated)
Study Completion 2027-02-03 (estimated)
Updated on ClinicalTrials.gov 2025-09-04