Microneedle Intra-Arterial Injection for Retinal Artery Occlusion

This prospective interventional study evaluates the efficacy and safety of direct intra-arterial microneedle injection combined with pars plana vitrectomy for acute retinal artery occlusion (including central retinal artery occlusion \[CRAO\] and branch retinal artery occlusion \[BRAO\] involving the macula or causing severe visual loss). The primary endpoint is best-corrected visual acuity (BCVA, LogMAR) at 1 month. Secondary objectives include assessing the effect of treatment timing and monitoring longitudinal changes in visual function and retinal structure over 12 months.

NCT Number	NCT07151755
Lead Sponsor	Second Affiliated Hospital, School of Medicine, Zhejiang University
Conditions	Central Retinal Artery Occlusion
Enrollment	24 participants
Start Date	2025-09-01
Primary Completion	2027-07-31 (estimated)
Study Completion	2027-07-31 (estimated)
Updated on ClinicalTrials.gov	2025-09-03