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Topical Versus Injection PRP for Olfactory Dysfunction

Study acronym: TOP-IN
StatusRecruiting
PhasePhase 3
Started
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Record History

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  1. Recruitment opened Show 6 more changesShow less
    • Primary endpoints: details revised at 1 of 1 entry
    • Start date changed from estimate of Oct 1, 2025 to Sep 11, 2025
    • Eligibility criteria expanded, about 6 words
    • Secondary endpoints: details revised at 4 of 9 entries
    • Site details revised
    • Publications: details revised at 5 of 5 entries
  2. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The goal of this clinical trial is to determine whether two different delivery methods of autologous platelet-rich plasma (PRP) can improve olfactory function in adults with persistent olfactory dysfunction lasting more than three months. The main questions it aims to answer are: 1. Does carrier-assisted topical application of PRP lead to comparable or better improvement in smell function than intranasal injection of PRP? 2. Which method provides greater patient comfort and fewer adverse effects? Researchers will compare carrier-assisted topical PRP application to intranasal PRP injection to see if one approach is more effective in restoring olfactory function. Participants will: 1. Receive a single PRP treatment delivered either by injection or via a PRP-soaked carrier placed into the olfactory cleft. 2. Continue daily olfactory training for three months following the intervention. 3. Undergo smell testing (Sniffin' Sticks) before and after treatment and complete quality-of-life questionnaires.
Trial Details
NCT Number NCT07151703
Lead Sponsor Taipei Veterans General Hospital, Taiwan
Conditions
(from sponsor)		 Olfactory Dysfunction, Anosmia, Hyposmia
Related terms Anosmia
Enrollment 60 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov