Efficacy of Bee Venom Phonophoresis in Treating Chronic Sinusitis:

This double-blind, randomized controlled trial (BEE-SONIC) aims to evaluate the efficacy of bee venom phonophoresis in the treatment of chronic sinusitis. Thirty adult patients (aged 18-65 years) with clinically diagnosed chronic or acute sinusitis will be randomized into two groups: the intervention group will receive bee venom phonophoresis using low-to-moderate intensity ultrasound, while the control group will receive standard care consisting of oral decongestants and saline nasal irrigation. Primary outcomes include improvement in symptom severity (SNOT-22, Visual Analog Scale) and quality of life (SF-33). Secondary outcomes include reduction in facial pain, nasal congestion, and patient satisfaction. Data will be collected at baseline, midpoint, and post-intervention, and analyzed using paired t-tests and ANOVA. The study has received ethics approval from Sinai University's Human Research Ethics Committee, and informed consent will be obtained from all participants.

NCT Number	NCT07151313
Lead Sponsor	Sinai University
Conditions	Chronic Sinusitis, Acute Sinusitis, Rhinosinusitis
Enrollment	30 participants
Start Date	2026-08-15
Primary Completion	2027-10-25 (estimated)
Study Completion	2027-12-25 (estimated)
Updated on ClinicalTrials.gov	2026-08-04