Cranial Electrotherapy Stimulation and Brain Imaging for Gulf War Syndrome

The main goal of the proposed study is to critically evaluate a nonpharmacological and readily available therapy, cranial electrical stimulation (CES) using Alpha-Stim™, and to discover the brain function mechanisms underlying Gulf War Illness-related Headache and Pain (GWI-HAP) and treatment response to CES. For this objective, the investigators will employ an adaptive trial design as well as a neuroimaging technique using MRI, which has become the pre-eminent technique for assessing the integrity of brain function, connectivity, and organization in healthy brain and pathology.

NCT Number	NCT07151248
Lead Sponsor	Emory University Collaborators: Congressionally Directed Medical Research Programs
Conditions	Gulf War Syndrome
Enrollment	130 participants
Start Date	2025-09-26
Primary Completion	2029-09 (estimated)
Study Completion	2029-09 (estimated)
Updated on ClinicalTrials.gov	2026-04-22