Clinical Trial

Retinal Detachment Prevention (Laser Prophylaxis) in Stickler Syndrome (SS)

Study acronym: OSC/SS
Recruiting
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Summary
The goal of this clinical trial is to prospectively document to what extent the OSC/SS prophylactic laser retinopexy procedure works to prevent retinal detachment in SS in children and adults. Researchers will compare the OSC/SS procedure in SS to the natural progression of SS to see to what extent the OSC/SS procedure works to prevent retinal detachment. Participants will: * Have the OSC/SS procedure in one or both eyes * Have eye tests * Have genetic testing for SS as needed * Visit the study center 9 times over 5 years for checkups and tests * Have data for the untreated fellow-eye collected and used as study data if available
Protocol Amendment History 8 amendments
This ClinicalTrials.gov record has been amended 8 times since 2025-08-22; most recent amendment 2026-06-29.
Status change: Not Yet Recruiting → Recruiting 2025-10-26
Trial Details
NCT Number NCT07146516
Lead Sponsor Helen Keller Eye Research Foundation
Collaborators: Five Lakes Clinical Research Consulting, LLC
Conditions Stickler Syndrome Type 1, Stickler Syndrome Type 2
Enrollment 500 participants
Start Date 2025-10-30
Primary Completion 2035-12 (estimated)
Study Completion 2035-12 (estimated)
Updated on ClinicalTrials.gov 2026-07-01