Prevalence of Liver Dysfunction in Pediatric Patients With Congenital Heart Disease at Assiut.

Liver dysfunction is a well-documented complication in patients with congenital heart disease (CHD). The mechanisms leading to hepatic dysfunction may be multifactorial. Key risk factors for liver dysfunction in CHD include prolonged hypoxemia, high venous pressure, and prolonged duration of heart disease. While global studies have extensively explored this association, the prevalence of liver dysfunction in CHD varies, with studies reporting hepatic fibrosis in 30-40% of Fontan patients, while regional data, particularly from Egypt, remain limited. In this research we aim to determine the prevalence of biochemical and radiological hepatic abnormalities in pediatric CHD patients attending Assiut University Children's Hospital.

NCT Number	NCT07144501
Lead Sponsor	Assiut University
Conditions	Congenital Heart Disease, Liver Dysfunction
Enrollment	40 participants
Start Date	2025-09-15
Primary Completion	2026-02-15 (estimated)
Study Completion	2026-03-15 (estimated)
Updated on ClinicalTrials.gov	2025-08-27