Clinical Trial

Effect of Systemic Retinoic Acid Use on Micro Ribonucleic Acid (mRNA) Expression

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Record status
This record was last updated August 26, 2025 (before its estimated December 31, 2025 completion). Its status may not reflect the trial's current state.
Summary
Ribonucleic acids (RNA) are molecules that transfer genetic information from the nucleus to the cytoplasm for protein translation. A subgroup of non-coding or non-messenger RNAs, known as microRNAs (miRNAs), regulates the expression of complementary mRNAs without coding for proteins. In this study, the investigators aimed to evaluate the effect of systemically administered oral isotretinoin on gingival health in terms of microRNA (miRNA), a molecule of interest in periodontal research, before, during, and after treatment.
Trial Details
NCT Number NCT07142070
Lead Sponsor Medipol University
Conditions Periodontal Diseases, Inflammation
Enrollment 25 participants
Start Date 2025-09-01
Primary Completion 2025-12-31 (estimated)
Study Completion 2026-02-01 (estimated)
Updated on ClinicalTrials.gov 2025-08-26