Clinical Trial

Short-term Low-dose Low-molecular-weight Heparin to Prevent Postpartum Thrombosis

Study acronym: SHINE
Recruiting Phase 3
View on ClinicalTrials.gov →
Summary
The goal of this clinical trial is to evaluate the risk-benefit of a short-term treatment with a low-dose low-molecular-weight heparin (LMWH), in the postpartum period (after delivery). The main questions it aims to answer are: * compared to no treatment, does short-term postpartum LMWH modify the risk of venous thromboembolism within 90 days of delivery? * compared to no treatment, does short-term postpartum LMWH modify the risks of bleeding and wound complications? Participants will take low-dose LMWH for 7-10 days or no treatment, and will be followed for 90 days post-delivery.
Protocol Amendment History 1 change
notable Trial sites expanded: 1 -> 8 locations 2026-07-25
Trial Details
NCT Number NCT07140211
Lead Sponsor Marc Blondon
Conditions Venous Thromboembolism (VTE), Postpartum
Enrollment 9,200 participants
Start Date 2025-10-15
Primary Completion 2030-08 (estimated)
Study Completion 2030-08 (estimated)
Updated on ClinicalTrials.gov 2026-07-24