Clinical Trial

Axillary Radiotherapy or Axillary Lymph Node Dissection in Patients With Clinically Node- Positive Breast Cancer Undergoing Upfront Tailored Axillary Surgery

Study acronym: OPBC-10/ NOAX
Recruiting
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Summary
This trial is to investigate if in patients with clinically node positive breast cancer undergoing upfront surgery, treatment with TAS and ART is superior to ALND in terms of arm-related Quality of Life (QoL) and occurrence of lymphedema two years after randomization.
Protocol Amendment History 1 change
notable Trial sites expanded: 36 -> 54 locations 2026-05-12
Trial Details
NCT Number NCT07140172
Lead Sponsor University Hospital, Basel, Switzerland
Conditions Breast Cancer
Enrollment 1,060 participants
Start Date 2026-01-01
Primary Completion 2029-12-31 (estimated)
Study Completion 2037-12 (estimated)
Updated on ClinicalTrials.gov 2026-08-07