Clinical Trial

Downstream Effects of Airway Mucus Plugs on 129Xenon MRI in Severe Asthma

Recruiting
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Summary
In this study, xenon MRI will be used to evaluate regional functional consequences of mucus plugs in the lungs of patients with severe asthma. Mucus plugs will be identified using CT imaging, and xenon MRI will be used to evaluate ventilation and gas exchange impairments in regions of the lungs corresponding to the airways downstream of mucus plugs.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2025-08-18; most recent amendment 2025-11-17.
Status change: Not Yet Recruiting → Recruiting 2025-11-17
Trial Details
NCT Number NCT07139899
Lead Sponsor Bastiaan Driehuys
Collaborators: University of Kansas Medical Center, Polarean, Inc.
Conditions Severe Asthma
Enrollment 5 participants
Start Date 2025-11-17
Primary Completion 2026-11 (estimated)
Study Completion 2027-09 (estimated)
Updated on ClinicalTrials.gov 2025-11-20