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Downstream Effects of Airway Mucus Plugs on 129Xenon MRI in Severe Asthma

StatusRecruiting
PhaseNot specified
Started2025-11-17
View on ClinicalTrials.gov ↗

Amendment history

2025-11-17
notable
Not Yet Recruiting→Recruiting Study Status, Contacts/Locations v2
Trial statusNot Yet Recruiting→Recruiting
Start dateestimated 2025-11-01→confirmed 2025-11-17
Study sitesdetails revised at 1 of 1 site
2025-10-14
minor
Study Status v1
Primary completion date2026-09→2026-11
Start date2025-09→2025-11-01
2025-08-18
minor
Original filing
918 trials monitored
See 29 trials at risk
In this study, xenon MRI will be used to evaluate regional functional consequences of mucus plugs in the lungs of patients with severe asthma. Mucus plugs will be identified using CT imaging, and xenon MRI will be used to evaluate ventilation and gas exchange impairments in regions of the lungs corresponding to the airways downstream of mucus plugs.
Trial Details
NCT Number NCT07139899
Lead Sponsor Bastiaan Driehuys
Collaborators: University of Kansas Medical Center, Polarean, Inc.
Conditions Severe Asthma
Enrollment 5 participants
Start Date 2025-11-17
Primary Completion 2026-11 (estimated)
Study Completion 2027-09 (estimated)
Updated on ClinicalTrials.gov 2025-11-20