Deciphering the Mechanisms of Central BP Regulation in Patients With PD Associated With Orthostatic Hypotension

Phase 1 objective: test the feasibility of using a 3Tesla MRI scanner instead of a 7Tesla MRI scanner to measure brainstem responses to LBNP in healthy participants. Phase 2 primary objective: compare the brainstem responses to LBNP in patients with PD associated with OH to PD patients without OH using BOLD fMRI

NCT Number	NCT07139756
Lead Sponsor	Centre Hospitalier Universitaire Vaudois Collaborators: Ecole Polytechnique Fédérale de Lausanne, University Hospital, Geneva
Conditions	Parkinson Disease, Orthostatic Hypotension
Enrollment	130 participants
Start Date	2025-10-01
Primary Completion	2027-09-30 (estimated)
Study Completion	2028-03-31 (estimated)
Updated on ClinicalTrials.gov	2025-08-24