Muscle Oxygenation in Patellofemoral Pain

Patellofemoral joint problems account for a significant portion of knee pain and disability. Among these problems, patellofemoral pain is not directly related to any obvious structural abnormality and is characterized by pain in the retro- or peri-patellar region, particularly during activities such as squatting, running, and climbing stairs. It is commonly seen in the general population. The current literature highlights the tendency of patellofemoral pain to recur and become chronic despite all treatments. Individuals with patellofemoral pain often experience disorders in the neuromuscular function of the quadriceps femoris muscle, which is necessary for knee function and dynamic stability and is frequently suggested to play an important role in the pathophysiology of the disease. A decrease in the tissue's ability to utilize oxygen during exercise or physical activity may lead to permanent dysfunction of the quadriceps femoris muscle. However, no studies have been found in the literature examining changes in oxygenation of the quadriceps femoris muscle in individuals with patellofemoral pain. Therefore, the aim of this study is to investigate changes in oxygenation of the quadriceps femoris muscle in individuals with patellofemoral pain during various exercises and physical activities by comparing them with pain-free individuals.

NCT Number	NCT07139158
Lead Sponsor	Ankara Medipol University Collaborators: Gazi University
Conditions	Patellofemoral Pain, PFP
Enrollment	41 participants
Start Date	2025-08-20
Primary Completion	2025-08-31 (estimated)
Study Completion	2025-08-31 (estimated)
Updated on ClinicalTrials.gov	2026-02-10