Testing of an Interface for Synchronizing tACS-DBS With a Phase-locked-loop

The investigators aim to test an interface to phase-lock transcranial alternating current stimulation (tACS) and deep brain stimulation (DBS) for future studies investigating the effects of different time-lags between DBS and tACS on the behavioural and neural level. To test if the interface works in patients with DBS, the investigators record EEG during synchronized tACS-DBS in several patients. The investigators hypothesize that they can apply tACS at the desired phase-lags relative to DBS pulses and confirm this with EEG measurements of the DBS and tACS artifact.

NCT Number	NCT07139093
Lead Sponsor	Universitätsklinikum Hamburg-Eppendorf Collaborators: University of Twente, University of Oxford
Conditions	Deep Brain Stimulation, Parkinson's Disease (PD)
Enrollment	2 participants
Start Date	2025-09-30
Primary Completion	2026-02-27 (estimated)
Study Completion	2026-02-27 (estimated)
Updated on ClinicalTrials.gov	2026-06-30