Optimizing Linezolid Dosing in Patients With Advanced Renal Impairment: a Therapeutic Drug Monitoring-based Evaluation

The goal of this clinical trial is to adjust the Linezolid dose according to its blood level in adults with kidney diseases. It will also learn about the safety of linezolid. The main questions it aims to answer are: * How often does linezolid require level monitoring? * How often does linezolid require dose adjustment? * What medical benefits do participants have when linezolid level monitoring is applied? Researchers will compare two dose reduction regimens when they have evidence of overexposure to determine which regimen is more effective in preventing thrombocytopenia (Platelet drop). Participants will: * Withdrew linezolid level every 2 to 4 days of the antibiotic course. * Visit the clinic twice for checkups and tests.

NCT Number	NCT07138521
Lead Sponsor	Alexandria University
Conditions	Kidney Disease
Enrollment	50 participants
Start Date	2025-10-15
Primary Completion	2025-12-15 (estimated)
Study Completion	2026-05-15 (estimated)
Updated on ClinicalTrials.gov	2025-08-24