The Impact of Nurse Practitioner-Led Multidisciplinary Team Intervention on the Implementation of Guideline-Directed Medical Therapy and Clinical Outcomes in Adults With Multimorbidity

The goal of this clinical trial is to evaluate whether a nurse practitioner-led multidisciplinary team (NP-led MDT) intervention can improve the use of guideline-directed medical therapy (GDMT) and short-term clinical outcomes in hospitalized adults with multimorbidity in a multidisciplinary medicine ward. The main questions it aims to answer are: Does NP-led MDT intervention increase the proportion of patients achieving GDMT at hospital discharge? Does NP-led MDT intervention reduce 30-, 60-, and 90-day readmission, emergency department visits, and mortality? Researchers will compare the NP-led MDT intervention group with the usual care group to see if the intervention improves GDMT implementation and clinical outcomes. Participants will: Be randomly assigned to NP-led MDT care or usual care. Have their medications reviewed according to the latest guidelines (intervention group only). Be followed for 90 days after discharge to collect outcomes through medical record review and telephone follow-up.

NCT Number	NCT07138183
Lead Sponsor	National Taiwan University Hospital
Conditions	Multimorbidity
Enrollment	178 participants
Start Date	2025-09-02
Primary Completion	2025-11-24 (estimated)
Study Completion	2026-04 (estimated)
Updated on ClinicalTrials.gov	2026-03-19