Psychological Options for Wellness and Recovery (POWeR) Trial for Veterans With Chronic Back/Neck Pain

The goal of this clinical trial is to learn which treatment works better for veterans with chronic neck or back pain. This study is comparing three treatments: Pain Reprocessing Therapy (PRT), Cognitive Behavioral Therapy (CBT), and usual care (whatever a person is already doing to cope with their pain). The main questions the study aims to answer are: 1. Which treatment works better for lowering pain: PRT, CBT, or usual care? 2. How do the effects of PRT compare with CBT and usual care in terms of pain relief and other factors such as emotional functioning, quality of life, anxiety, and pain medication use? Participants will: 1. Be randomly assigned to receive either PRT, CBT, or usual care. 2. Complete questionnaires about their pain and health. 3. If in the PRT or CBT group, have nine weekly therapy sessions over video calls with a therapist.

NCT Number	NCT07137715
Lead Sponsor	University of Colorado, Denver Collaborators: VA Eastern Colorado Health Care System, United States Department of Defense
Conditions	Chronic Pain, Back Pain, Back Pain Lower Back Chronic, Neck Pain
Enrollment	360 participants
Start Date	2026-03-27
Primary Completion	2028-01 (estimated)
Study Completion	2028-09 (estimated)
Updated on ClinicalTrials.gov	2026-03-31