Clinical Trial

Fundus-first Laparoscopic Cholecystectomy

Study acronym: FFLC
Completed
View on ClinicalTrials.gov →
Summary
Bile duct injury (BDI) remains the most feared complication of laparoscopic cholecystectomy, particularly in difficult gallbladder cases. The fundus-first technique has emerged as a potentially safer alternative to classical laparoscopic cholecystectomy for challenging cases. This single-center, prospective, randomized controlled trial compared the efficacy and safety of fundus-first laparoscopic cholecystectomy (FF-LC) versus classical laparoscopic cholecystectomy (C-LC) in 174 patients with difficult gallbladder characteristics. The primary outcome was bile duct injury rate. Secondary outcomes included conversion to open surgery, operative parameters, and postoperative complications.
Protocol Amendment History 3 amendments
This ClinicalTrials.gov record has been amended 3 times since 2025-08-15; most recent amendment 2026-02-17.
Status change: Active, Not Recruiting → Completed 2026-02-17
Status change: Recruiting → Active, Not Recruiting 2025-11-30
Trial Details
NCT Number NCT07137546
Lead Sponsor Minia University
Conditions Cholecystitis, Acute Cholecystitis, Pericholecystic Abscess
Enrollment 174 participants
Start Date 2024-05-01
Primary Completion 2026-02-01 (estimated)
Study Completion 2026-02-17 (estimated)
Updated on ClinicalTrials.gov 2026-02-19