CRF influences engagement in everyday activities, mood, sleep, social relations, school attendance, academic achievement, and quality of life . It was significantly associated with low health-related quality of life in pediatric cancer patients including leukemia . Since attention to managing cRF has been drawn, only a few non-pharmacological strategies were tested for their effectiveness in reducing cRF among children. Physical activity (Pa) has been proven to be the most effective strategy . Yet adherence to Pa remains problematic.
Protocol Amendment History
3 amendments
This ClinicalTrials.gov record has been amended 3 times since 2025-08-16; most recent amendment 2026-02-28.
Status change: Recruiting → Completed2026-02-28
Status change: Not Yet Recruiting → Recruiting2025-11-14